A study of chromium levels in type 2 diabetes mellitus
Dr. Mohammad Rafi, Dr. S Laxmi Narayana
Chromium is one of the most abundant elements in the earth’s crust. It is an essential trace element for proper insulin functioning and blood glucose regulation. The present study was undertaken in the Dept. of Biochemistry, Gandhi Medical College, Musheerabad, Secunderabad, Telangana, India, to assess the concentrations of chromium in the serum samples of the patients of Type 2 Diabetes mellitus attending the outpatient Department of Gandhi Hospital, Secunderabad. The study is also intended to assess chromium handling in Type 2 Diabetes mellitus patients compared to healthy controls. The study comprised of total n=40 subjects consisting of n=20 subjects of Type 2 Diabetes mellitus and n=20 cases normal healthy controls, between 40-70yrs which were further categorized into Group I n=10 subjects between 40-54 yrs and Group II n=10 subjects between 55-70 yrs. In both the study and control group subject’s serum chromium level was measured with flame atomic absorption spectrophotometer. The data of mean levels of serum chromium concentrations in the normal individuals (controls) and Type 2 Diabetes mellitus subjects showed highly significant differences between the two groups (p<0.001). The mean level of serum chromium concentration in the normal control individuals was 0.478 µg/L and SD±0.10 and in the subjects with Type 2 Diabetes mellitus, the concentration was 0.278±0.10. The mean chromium concentration in the normal individuals between 40-54 yrs age group was 0.523±0.08 while 0.443±0.06 between 55-70yrs age group showing significant differences between the two age groups (p<0.05). The results of this study showed significantly low chromium concentrations in the serum of Type 2 DM subjects compared to that of normal healthy controls (p<0.001). Results also indicate lower concentrations of chromium in elderly groups (55-70yrs) of normal individuals when compared to the relatively younger group (40-55 yrs) (p<0.05). No significant difference was observed between different age groups of diabetic patients, probably because of already compromised chromium status in them. The above observations are in support of giving supplemental chromium to the patients of Type 2 Diabetes mellitus.