Assessment of different routes of administration of misoprostol in first and second trimester abortions
Dr. Bibha Jha, Dr. Asha Jha
Misoprostol can also be used to dilate the cervix in preparation for a surgical abortion, particularly in the second trimester (either alone or in combination with laminaria stents). Hence, the present study was carried out to compare the effectiveness of 400 μg of misoprostol through three different routes i.e. vaginal, sublihgual and oral for first and second trimester abortion as per MTP act. The present study was planned in the Department of Obstetrics and Gynaecology, Darbhanga Medical College and Hospital from Jan 2017 to Sept 2017.Total 75 females with a period of gestation between 12 and 20 weeks scheduled to have pregnancy termination as per MTP Act were included in the study. The all enrolled females were divided in three equal study groups based on the administration route of Misoprostol. The Group I, II and III were administered with the Misoprostol 400 mcg at 4-hourly interval by Sublingual, Vaginal and Oral route. The misoprostol was administered with 400 mcg at 4-hourly interval up to a maximum of four doses each. The data generated from the present study concludes that Oral and sublingual routes of administration have shown to be more tolerable related to vaginal route of administration. But the effectiveness of oral administration is less. Thus, sublingual misoprostol has the advantage that it can evade the uncomfortable vaginal administration. Also absorption of the drug may be affected when the patient starts bleeding.