Vol. 5, Issue 7 (2019)
Clinical evaluation of serum iron levels in rheumatoid arthritis patients in darbhanga medical college and hospital
Author(s): Dr. Devendra Kumar Sinha
Abstract: Ferritin a key protein of iron metabolism is capable of dual function in iron detoxification and iron storage present in serum and biological fluids. It is a multimeric protein consists of 24 subunits of types H and L which surrounds a cavity in which iron can be stored in a readily available non-toxic form. The synthesis of ferritin is regulated by cytokines at various levels of protein synthesis, during cellular differentiation, proliferation and inflammation. The expression of ferritin is also regulated by hormones, growth factors, second messengers and hypoxia. Both oxidant and antioxidants response inducers regulate ferritin gene transcription. During certain conditions the deregulation of ferritin cause this intracellular iron storage protein to act as prooxidant. Therefore the present study aims to determine the ferritin level in RA and its response to oxidative stress. The present study was planned in Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar from July 2018 to Feb 2019. Total 40 patients were enrolled in the present study. The patients were divided in two groups for comparative study of different parameters. The Group I consist of 20 patients diagnosed with Rheumatoid arthritis were enrolled for the study. The group B consist of 20 control patients for comparative evaluation. The present study concludes that anemia is a common extra articular manifestation of Rheumatoid arthritis and anemia of chronic disease is the commonest type of anemia in Rheumatoid arthritis, however there is a high prevalence of iron deficiency anemia in RA in this part of country. There is no known prevention for iron deficiency anaemia in rheumatoid arthritis (RA) patients other than the reduction of contributory factors. Therapy goals are to reduce pain and inflammation and improve quality of life. Surgery to repair, replace or fuse joints may help in serious conditions.
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