Vol. 5, Issue 8 (2019)
A study of glycated hemoglobin (HbA1C) in non diabetic hypothyroid population of Gujarat, India
Author(s): Dr. Sandeep Barve, Dr. Krishna Kant Shiromani, Dr. Usha Amliyar
Abstract: Background: Glycated hemoglobin (HbA1c) can be altered in different conditions. We hypothesize that HbA1c levels may change due to altered thyroid status, possibly due to changes in red blood cell (RBC) turnover. Objective: The Objective of the study is to measure glycated hemoglobin (HbA1C) in non diabetic hypothyroid population Material and Methods: Study includes total 200 partcipants and they were divided in to case (n=100, Among them 50 hypothyroid and 50 euthyroid) [25 microcytic hypochromic anaemia, 25 normocytic normochromic anaemia and 50 non anemic patients] and age and sex matched healthy control (n=100) group.HbA1C level,plasma glucose level and anemia status of all participants were assessed. Anaemia status was determined by Hemoglobin, red cell indices and peripheral smear and Glycemic status was determined by fasting Plasma glucose and HbA1c.Obtained data was analyzed statistically and compared with each other to see the difference of significance by calculating p value. Results: The Glycated hemoglobin (HbA1C) level in hypothyroid patients with microcytic hypochromic anaemia was 6.40 ± 0.57% and normocytic normochromic anaemia was 6.22 ± 0.41%. The HbA1C level levels in euthyroid patients with microcytic hypochromic anaemia was 6.42 ± 0.98% and normocytic normochromic anaemia was 6.0± 0.39 % While hypothyroid non anemic patients showed A1C levels of 5.9 ± 0.29% against 5.39 ± 0.68% of euthyroid non anemic controls. Conclusion: Baseline HbA1c levels were found to be significantly higher in hypothyroid patients compared to control individuals despite similar glucose levels. HbA1c reduced significantly with treatment in hypothyroid patients without a significant change in glucose levels. Significant baseline or posttreatment change was not observed in hyperthyroid patients. Our study suggests that HbA1c data should be interpreted with caution in patients with hypothyroidism.
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