Vol. 5, Issue 8 (2019)
Clinicopathological correlation in liver biopsy of cirrhosis
Author(s): Dr. DG Jaiswal, Dr. SD Dakhure
Abstract: Background: Liver disease has steadily gained recognition as a major health problem principally because of the world wide epidemic of hepatitis and ubiquity of cirrhosis of liver. Alcohol is considered to be a major etiological factor in western world, whereas viral etiology is considered to be predominant cause of cirrhosis in Indian subcontinent. Early diagnosis and specific treatment for etiology can reverse the cirrhosis. Material & Methods: This retrospective study was carried out in the Department of Pathology, Government Medical College, and Aurangabad. Tissue bits from liver biopsy were preserved in 10% formalin. These were processed and paraffin sectioning was done followed by Haematoxylin and Eosin staining. The sections were then examined microscopically. Results: Out of 60 cases of cirrhosis, 47 cases (78.33%) were males and 13 cases (21.66%) were females with maximum numbers of cases, in age group of 31-60 years were 43 cases (71.66%). The most common presentation were ascites, oedema and abdominal distention. Predominant morphological pattern was micronodular cirrhosis (76.66%) and least type was mix pattern. (3.31%) Conclusion: Alcohol remained the most common etiology of cirrhosis most commonly in males. The early diagnosis of liver disease may prevent the progression of disease severity and may also prevents the cirrhosis. Therefore, if there is no contraindication, for confirmation of diagnosis liver biopsy still remains a useful diagnostic tool modality, even in the era of advanced virological, immunological and molecular genetic testing.
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