Evaluation of vitamin B12 deficiency in patients diagnosed with pancytopenia
Dr. Vijay Lal
Vitamin B12 deficiency is a common cause of megaloblastic anemia and pancytopenia. Cutaneous manifestations associated with vitamin B12 deficiency are skin hyperpigmentation, vitiligo, angular stomatitis, and hair changes. Vitamin B12 plays an important role in DNA synthesis, the deficiency of which is associated with myriad of hematologic, neurologic, psychiatric, gastrointestinal, dermatologic, and cardiovascular manifestations. Hence based on above findings the present study was planned Evaluation of Vitamin B12 Deficiency in Patients Diagnosed with Pancytopenia. The study was conducted in Department of General Medicine, IGIMS, Patna, Bihar, India. The study was done from the September 2018 to June 2019. In the present study 50 patients diagnosed with the pancytopenia were enrolled and evaluated. Detailed clinical history and meticulous examination was carried out in all the patients. All possible relevant investigations and the etiology were carried out. Bone marrow examination was done in selected patients where it was indicated. The data generated from the present study concludes that vitamin B12 and Folate deficiency is the leading cause of pancytopenia in India especially in younger population. Significant proportions of cases were reversible with early diagnosis and intervention and had favourable outcome. Physicians should have a high index of suspicion for vitamin B12 deficiency when dealing with patients presenting with symptoms of anaemia such as pallor and weakness or diagnosed with pancytopenia on haematological examination. Clinical findings along with haematological analysis are very important for the early diagnosis of both the diseases in order to start early intervention, so that survival rates may be increased.