Evaluation of serum lipid profile in patients on maintenance hemodialysis
Rolly Bharty, Anand
This hospital-based cross-sectional comparative observational study was performed to determine the pattern of lipid profile in patients on maintenance hemodialysis. The study was performed at the Department of Biochemistry, Jawaharlal Nehru Medical College Hospital, Bhagalpur, Bihar, India from May 2020 to September 2020. Fifty patients with end-stage renal disease on maintenance hemodialysis (MHD) were studied. They comprised of 30 males and 20 females, the mean duration on hemodialysis was 7.58 ± 2.05 yrs, with frequency of 02 to 03 sessions per week and each session lasting for 04 hours. Additionally, 25 healthy volunteers (15 male, 10 female) were also studied. After obtaining informed, written consent, general information of each patient was recorded on the preformats. After 12-hours fasting, with all due universal precautions blood samples were drawn from the arterio-venous fistula before starting dialysis. The samples were analyzed in autoanalysers with their recent quality control examinations. The total cholesterol, triglyceride (TG) or low density lipoprotein (LDL) levels more than 95th percentile for age and gender or high density lipoprotein (HDL) less than 35 mg/dL is defined as Dyslipidemia. Descriptive and inferential statistical analysis was performed using SPSS version 16.0. The age among MHD and control groups was 47.88 ± 13.92 and 54.56 ± 11.16 years respectively. Serum TG and lipoprotein-a (LPa) were significantly increased (P= < 0.001 for each) while HDL-c was significantly lower (P= < 0.001) in MHD patients than in the control group. The serum cholesterol, LDL-c, VLDL-c and chylomicron levels were not significantly different in the two groups. Our study suggests that patients on MHD show abnormalities of lipid metabolism like hypertriglyceridemia, elevated lipoprotein-a & low HDL-c, which could contribute to atherosclerosis and cardiovascular disease that may increase the morbidity and mortality in these patients.