Chronic kidney disease (CKD) is an increasingly recognized major public health problem globally and in Nepal. It has a high prevalence in the population and is associated with high morbidity, mortality and health care costs. Chronic kidney disease (CKD) has a complicated interrelationship with other diseases. Management of CKD patients therapeutically is complicated due to co-morbidities and various complications of CKD, non-adherence to treatment is an overgrowing problem for patients with CKD. Hence, the present study is carried out to assess the management practice, medication adherence and non-adherence at tertiary care hospital.