Aim of The Study: The present study was designed to determine the drug utilization pattern and cost analysis of anti-fungal drugs used in dermatology OPD of a tertiary care in teaching hospital (UCMS). Materials and methodsStudy Design: Prospective, observational study, cross sectional study Study Site: Dermatology department of tertiary care at UCMS Teaching hospital Sample Size: Minimum 200 patients Study Duration: November 2016 to January 2017 After taking Ethics committee’s permission, prescriptions of 200 patients attending Dermatology OPD, were audited. The prescriptions were analyzed for common skin conditions drug utilization and cost analysis. Results: This prospective, record based, observational study was carried out in Dermatology department in UCMS from November 2016 to January 2017. Patients diagnosed with fungal disorder by dermatologist were included in study as per inclusion Criteria. Data were collected and analyzed for drug utilization pattern, prescribing indicators and cost. Total 200 patients were included for the analysis. Combination therapy was most commonly prescribed than monotherapy. Most commonly prescribed antifungal agent was Ketoconazole 125 (19.65%) Itroconazole (13.36%) and Antihistaminic agent was levocetrizine 89 (13.99%). Average number of drugs prescribed per encounter was 3.18%. Drugs prescribed by generic name was 0%. Percentage of drugs prescribed from national list of essential medicine was 38.88%. Antifungal drug was available some % discount on outside pharmacy but not on hospital pharmacy. Conclusion:The dermatological prescription analysis gives a message to the prescribing Physician to achieve rational, cost effective medical care and will be prescribed by generic name.