Aim: To find out the association between serum albumin and clinical outcome in acute ischemic stroke. Material and Method: The present prospective cross-sectional study was conducted in the department of Medicine at Chattrapati Shivaji Subharti Hospital from April 2018 to December 2019 among 100 patients, aged 18 years and above with decompensated heart disease, without pre-existing renal disease. Hypoalbuminemia is defined as serum albumin level less than 3.5 gram per deciliter. Severity of stroke at admission was assessed using the NIHSS scale. All baseline investigations including FBS and serum albumin was measured. CT scan of the brain was done for all patients. Serum albumin level was analysed within 36 hours of admission. Pearson correlation analysis was used to correlate serum albumin, NIHSS score & MRS score. Results: 56% of study subjects had MCA infarct, 20% had multi-infarct, 6% had posterior circulation stroke, and 18% had Lacunar stroke. MRS score was significantly associated with the NIHSS Score. Among 41% study subjects, serum albumin level was low (<3.5g/dl). NIHSS score showed statistically significant results when associated with serum albumin. Significant positive correlation was found between Serum Albumin & NIHSS score (0.61), while a negative correlation was seen between Serum Albumin & MRS score (-0.67), and NIHSS score & MRS score (-0.82). Conclusion: Serum Albumin levels have significant association with the severity as well as short term functional outcome of ischemic stroke. Improving serum albumin levels may improve the functional outcome of acute ischemic stroke.