International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 7, Issue 5 (2021)

Association of MTR, MTRR, MTHFD1 and RFC-1 gene polymorphisms and head and neck squamous cell carcinoma in north Coastal Andhra Pradesh


B Papa Kusuma, V Lakshmi Kalpana, H Uma Bharathi, A Anuradha, V Aren

Aim: Head and neck cancer is identified by diverse group of malignant tumors that can develop in or all around the mouth, throat, nose and sinuses. It is a rather general multifactorial malignancy. The aim of the present study was to investigate the association of MTR (A2756G); MTRR (A66G); MTHFD1 (G1958) and RFC-1(G80A) gene polymorphisms in head and neck squamous cell carcinoma (HNSCC) patients and controls in North Coastal Andhra Pradesh. Materials and methods: A total of 220 samples (110 HNSCC patients and 110 controls) were included in the present study and genotyping was accomplished by using PCR - RFLP technique. Data was analyzed by SPSS 19 software. Results: The chi square p values revealed that MTR (A2756G) and RFC-1(G80A) gene polymorphisms has shows association with HNSCC and MTRR (A66G) and MTHFD1 (G1958)gene polymorphisms does not shows association with HNSCC. For MTR (A2756G) polymorphism the odds ratio p values of genotypes AG and GG were statistically significant, whereas AA genotype was found to be statistically insignificant. For MTRR (A66G) polymorphism the odds ratio p values of genotypes AA, AG and GG were found to be statistically insignificant. For MTHFD1 (G1958) polymorphism the odds ratio p values of genotypes GG, AG and AA were found to be statistically insignificant. For RFC-1(G80A) polymorphism the odds ratio p values of genotypes AG and GG were statistically significant, whereas AA genotype was found to be statistically insignificant. Conclusions: In conclusion, the MTR (A2756G) and RFC-1(G80A) gene polymorphisms shows association with HNSCC, whereas MTRR (A66G) and MTHFD1 (G1958) gene polymorphisms does not shows association with HNSCC.
Pages : 36-44