Aim: To evaluate the drug resistance pattern in cases of Diabetes with Pulmonary Tuberculosis in western UP.Material and Method: The present hospital based study included 50 patients presenting to the Department of TB and Respiratory Diseases and Department of General Medicine at Chattrapati Shivaji Hospital of Subharti Medical College, Meerut, Uttar Pradesh between November 2018 to August 2020. Patients with DM and MDR-TB who were attending the OPD and admitted in IPD of Department were enrolled in the study. A good quality specimen, one with volume of 2-5 ml, preferably muco-purulent and not heavily blood stained or contaminated was collected from the patients after giving proper instructions. DST of Mycobacterium tuberculosis was performed using absolute concentration method on L-J media, and all procedures were carried out in accordance with the guideline of WHO.Results: Multidrug resistant tuberculosis (MDR-TB) was reported among 47.62% of the subjects with HbA1c 7 to 9 and among 2.38% of the subjects with HbA1c >9. H mono resistance was revealed among 33.33% of the subjects with HbA1c 7 to 9 and among 13.33% of the subjects with HbA1c >9. Mortality was revealed among 4 subjects, out of which 25% were having HbA1c 7 to 9 and 75% were having >9 HbA1c. Conclusion: From the results of our study, we suggest that each and every patient must be screened for diabetes before starting ATT.