Aim: To evaluate the safety and feasibility of PRP injections in a subset of patients treated for ED.Material and Method: The present prospective study was conducted among 28 subjects suffering from erectile dysfunction (ED) in the Department of Urology, Sawai Man Singh Hospital Jaipur. The study was approved by the Institutional Ethical Committee of the hospital. Data was prospectively collected and retrospectively reviewed for patients treated with PRP for ED by a single surgeon. Informed consent was obtained and patients were aware of off-label use. Demographic data, procedural details, outcomes data, and pre- and post-procedural International Index of Erectile Function (IIEF- 5) questionnaires (for male patients) were collected. Erectile function was evaluated using IIEF-5 scores (24 points in total). Scores below 21 points suggested ED. Each participant was injected with autologous PRP using a proprietary system.Results: None of the subject had normal IIEF score before the treatment. Post treatment, normal IIEF score was found among 57.14% and 71.43% of the subjects at 1 and 3 month respectively. Mean IIEF-5 scores increased from 15 to 20 after the administration of the PRP at 3 month with statistically significant difference. Treatment with PRP leads to erection hardness and ability to engage in a successful intercourse among 75% and 71.43% of the subjects respectively.Conclusion: The results of the current study were very promising regarding the function improvement of ED patients. After three months of follow-up, patients injected with PRP seemed to have better sexual life.