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VOL. 1, ISSUE 3 (2015)
Crucial Role of Nifedipine on Stabilizing Blood Pressure in Sinoaortic Denervated Rats
Authors
Jin Wang, Xiu-Juan Ma, Ding-Feng Su
Abstract
Background: The present work was designed to investigate the possible synergism of nifedipine and captopril, nifedipine and atenolol, and nifedipine and hydrochlorothiazide on lowering and stabilizing blood pressure (BP) in sinoaortic-denervated (SAD) rats.
Methods: Fifty-six SAD rats were randomly divided into 7 groups. They were respectively given nifedipine (3.0mg/kg), captopril (100mg/kg), atenolol (10mg/kg), hydrochlorothiazide (20mg/kg), and combined nifedipine and other three drugs. The drugs were given via a catheter in a gastric fistula. BP was recorded for 5h from 1h before drug administration to 4h after administration, in conscious, freely moving rats.
Results: It was found that combination of nifedipine and others three drugs much significantly decreased BP and BP variability than these drugs alone. The q values calculated by probability sum analysis were all between 1.20 and 2.50 for SBP, DBP, SBPV and DBPV for the combination of nifedipine and others three drugs.
Conclusion: The present work clearly demonstrated that there is a synergistic effect between nifedipine and captopril, nifedipine and atenolol, and nifedipine and hydrochlorothiazide in lowering and stabilizing the BP. Nifedipine made the crucial role on lowering and stabilizing the BP in SAD.
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Pages:55-58
How to cite this article:
Jin Wang, Xiu-Juan Ma, Ding-Feng Su "Crucial Role of Nifedipine on Stabilizing Blood Pressure in Sinoaortic Denervated Rats". International Journal of Medical and Health Research, Vol 1, Issue 3, 2015, Pages 55-58
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