International Journal of Medical and Health Research

Authors
Dr. Arun Tyagi, Dr. Nikhil Jariwala, Dr. Sharad Garudkar, Dr. Shashank Telang, Dr. Mukul Bedi

Abstract

Obesity, particularly abdominal obesity, is associated with Insulin resistance. The associated hyperinsulinemia and hyperglycaemia and adipokines may also lead to vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation, all of which are the components of the metabolic syndrome. Metabolic syndrome is a multifactorial and insulin resistance appears to be the primary mediator of metabolic syndrome. The present study was undertaken to study the prevalence of insulin resistance in apparently healthy population.

The methods used to assess insulin resistance clinically were- 1. Insulin Sensitivity Index (ISI), 2. American Diabetes Association Score (ADA), 3. Finnish Diabetes Risk Score and 4. Indian Diabetes Risk Score (IDRS). The total number of patients studied was 150. After detailed medical history, each patient underwent laboratory investigations of urinalysis, Fasting Blood Sugar estimation, blood urea, serum creatinine levels and a fasting Lipid Profile. Metabolic syndrome was measured using ATP III revised criteria 2005. Insulin Resistance was calculated for all subjects using all four different methods and later results were compared with each other. The relationship of each risk factor with Insulin Resistance was also calculated and studied statistically. This study revealed significantly high prevalence of Insulin resistance in 40% of apparently normal individuals as measured by ISI method. It confirms the fact that high insulin resistance is the predecessor and precursor of the metabolic syndrome and can be and should be detected in normal individuals for implementing effective preventive measures.