Background: Oxidative stress is found to be one of the causes of hypertension. Serum Bilirubin is found to be an antioxidant and participates in defense mechanism against oxidative stress.rnAims & Objectives: To see relation between serum bilirubin and hypertension along with MDA (Malondialdhyde).rnMethodology: In the present study serum MDA and Serum bilirubin was measured in 25 patients with hypertension and 25 normotensive healthy adults showing family history of CAD.rnResults: The mean concentration of S.bilirubin (mg/dl) in hypertensive study group is 1.13±0.2 and that of control group is 0.56±0.3. The mean concentration of S.MDA (mmol/L) in hypertensive study group is 5.1±1.3 and that of control group is 1.5±1.1.rnConclusion: The subjects with higher bilirubin level showed a lower incidence of hypertension than did the subjects with lower bilirubin level. In humans, the effects of mildly increased serum bilirubin levels have been reported to be a decreased risk for the development of coronary artery disease and atherosclerosis.