International Journal of Medical and Health Research

Authors
Fayed Al-Yousofy, Hussein Gumaih, Hassan Ibrahim, Afrah Alasbahy

Abstract
Parsley is a medicinal plant used widely in urolithiasis. The present study aimed to evaluate the antiurolithiatic effect of parsley and its mechanism. 24 rats divided into four groups: group A (negative control), group B (positive control), group C (cystone® group) and group D (parsley group). Group B were treated with EG and Ammonium chloride (AC). Group C were treated as B plus cystone® and group D was treated as B plus parsley. The period of experiment was 15 days. Urine samples were analysis on days 0 and 15 days. Kidneys of rats from all groups were removed, a histopathologically examined. The kidney of parsley treated group appeared mostly to be calculi-free (less CaOx) even better than the cystone treated group. CaOx crystals was significantly lower both in histological sections and in urine samples in parsley treated group. We further investigate the mechanism of parsley by adding another 6 rats. The latter treated by parsley only after adaptation period. We found significant increase in urine volume and pH in parsley treated rats compared to negative control. We conclude that parsley act as antiurolithiatic drug through decreasing urinary calcium excretion, increasing urinary pH, diuresis and decreasing urinary protein excretion and its nephroprtective activity. We recommend to use it in pharmaceutical forms as it is safe and effective as antiurolithiasis remedy.