Leptin in prehypertension and essential hypertension and it's association with obesity

Nelapati Swetha Vinela; M Vijaya Bhaskar; T Praveen

Leptin in prehypertension and essential hypertension and it's association with obesity

Authors
Nelapati Swetha Vinela, M Vijaya Bhaskar, T Praveen

Abstract
Hypertension may be defined as sustained elevation of systemic arterial pressure above 140/90mm of Hg. It is the level of pressure at which institution of therapy reduces related morbidity and mortality. Leptin is a 167 amino acid hormone, produced by adipose tissue that helps to control energy balance by inhibiting hunger. It also plays role in other physiological processes like sympathetic nerve system activation, renal hemodynamics, blood vessel tone and blood pressure. The present study was designed to evaluating the clinical significance of serum leptin levels in pre-hypertension and essential hypertension affected individuals.

Samples were collected from newly diagnosed 100 cases of prehypertension and 100 cases of essential hypertension.

These groups were further subdivided into obese and non-obese based on waist circumference (WC) values. Leptin levels were quantitatively measured by ELISA assay. Statistical analysis was done by t- test.

The present study revealed a significant increase in serum leptin levels in prehypertension when compared with essential hypertension. Elevated levels of leptin were observed in obese than in non-obese in both groups.

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