International Journal of Medical and Health Research

The basic physiology of a seizure episode is detected to in an unstable cell membrane or its surrounding/adjacent supportive cells. The seizures originate from the grey matter of any cortical or subcortical area. Cytokines and other inflammatory mediators play an important role in epileptogenesis. Inflammations in human epileptic brain have been evidenced. Cytokines are important factors to cause neuronal excitability. Neurochemical changes are the main mechanisms underlying in epilepsy. These include GABA, catecholamine, alterations of ionic environment viz. potassium channels, sodium channels and calcium channels. Thus, the involvement of oxidative stress in epileptogenesis is well reported.