International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 10 (2016)

Pathophysiology of epilepsy: An updated review


Sandeep Kumar, Govind Singh

The basic physiology of a seizure episode is detected to in an unstable cell membrane or its surrounding/adjacent supportive cells. The seizures originate from the grey matter of any cortical or subcortical area. Cytokines and other inflammatory mediators play an important role in epileptogenesis. Inflammations in human epileptic brain have been evidenced. Cytokines are important factors to cause neuronal excitability. Neurochemical changes are the main mechanisms underlying in epilepsy. These include GABA, catecholamine, alterations of ionic environment viz. potassium channels, sodium channels and calcium channels. Thus, the involvement of oxidative stress in epileptogenesis is well reported.

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How to cite this article:
Sandeep Kumar, Govind Singh. Pathophysiology of epilepsy: An updated review. International Journal of Medical and Health Research, Volume 2, Issue 10, 2016, Pages 32-36
International Journal of Medical and Health Research