Thyroid dysfunction among type 1 diabetic patients; the time for induction of screening strategies by family physician
Mohammad Alkot, Hossam Abdelbaki, Abdulah Y Anewirah, Abdulaziz T Bagasi, Abdullah A Alshamrani, Abdulaziz J Alzahrani, Ameera M Alotaibi, Hussam O Alfaqih
Background: Diabetes mellitus and thyroid dysfunctions are the most two common endocrinopathies seen in family practice. Type 1 diabetes mellitus (T1DM) is frequently associated with autoimmune thyroid diseases (ATD). Genetic susceptibility to autoantibodies formation in ATD and T1DM has been described with varying frequencies, but there is still debate about the situation in the Saudi Arabia. Objectives: The main objective is health promotion of type 1 diabetic patients (T1DPs) assuring a better quality of their life. The specific objectives were to determine the prevalence of thyroid dysfunction among T1DPs, to clarify the effect of one on the other, and to assess the need for screening of thyroid dysfunction among T1DPs. Methods: A cross-sectional comparative study was conducted on all eligible T1DPs (No 310) who later were assigned as a case group and 320 non-diabetics with matched age, sex and socioeconomic criteria as a control group after their consent. They were subjected to full history taking, thorough clinical examination, and laboratory estimation of TSH, free T4, freeT3 and thyroid peroxidase antibodies (TPO-Abs). The case group was further subjected to glycosylated hemoglobin and lipid profile as indicators of diabetes control and dyslipidemia. Results: Prevalence of thyroid disorders was significantly higher among T1DPs constituted 21.9% versus 9.7% in non-diabetics. Most cases of thyroid dysfunction (67.7%) were hypothyroidism. Type1diabetes and thyroid dysfunctions were significantly affected by each other (P<0.05). Furthermore, thyroid dysfunction may significantly amplify the diabetic complications through inter-relationships with dyslipidemia. Conclusions: The family physician is in a prime position for conduction of a systematic screening approach for thyroid dysfunctions among T1DPs assuring adequately controlled T1DM with a high quality of life.
Mohammad Alkot, Hossam Abdelbaki, Abdulah Y Anewirah, Abdulaziz T Bagasi, Abdullah A Alshamrani, Abdulaziz J Alzahrani, Ameera M Alotaibi, Hussam O Alfaqih. Thyroid dysfunction among type 1 diabetic patients; the time for induction of screening strategies by family physician. International Journal of Medical and Health Research, Volume 2, Issue 12, 2016, Pages 13-18