The human immunodeficiency virus remains a global health problem since its discovery in 1983. The number of people living with HIV in India is estimated to be a little over 21 lakhs. Paucity of resources and manpower make the management of this disease a greater challenge in our country. In September 2015, the World Health Organization made its recommendations based on several peer reviewed sources and studies which stated that anti-retroviral therapy must be initiated for all patients, irrespective of CD4 counts. UNAIDS estimated that early ART might avert 28 million AIDS related deaths and prevent 28 million infections across all age groups by 2030. Various guidelines have been instituted for effective management. This article aims to consolidate current concepts for management of HIV/AIDS and also give a glimpse into future research in the field of management of HIV/AIDS.