Recent advances in molecular pathogenesis of multiple myeloma – Role of cytokine: Review of literature
Dr. Lohit kumar Kalita, Dr. Bhubaneswar saikia
There is a growing body of evidence that a network of cytokines is involved in the growth, progression, and dissemination of multiple myeloma. Some are actually produced by the malignant plasma cells including interleulkin-1 beta (IL-1β) tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor (VEGF), and a functionally active truncated version of macrophage colony-stimulating factor (M-CSF). These and other cytokines act as mediators of tumor cell growth, survival, migration, and development of drug resistance.
Dr. Lohit kumar Kalita, Dr. Bhubaneswar saikia. Recent advances in molecular pathogenesis of multiple myeloma – Role of cytokine: Review of literature. International Journal of Medical and Health Research, Volume 2, Issue 3, 2016, Pages 43-45