International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 2, Issue 5 (2016)

Study of antimicrobial resistance in enterococci at J.L.N medical college and associated Group of Hospitals, Ajmer, Rajasthan


Dr. Surbhi Mathur

Background: Enterococci were originally classified as enteric gram-positive cocci and later, included in the genus streptococcus. The intrinsic and acquired antimicrobial resistance properties of enterococci, to several antibiotics, have enabled them to survive in clinical environment enterococci acquire resistance to several available antimicrobial agents by either mutation or by receiving the foreign resistant determinations through plasmids & transposons.rnObjective: The Aim of this research work is to study antimicrobial resistance in enterococci.rnMethodology: The present prospective study was conducted on 125 pure isolates (1 per patient) of enterococci isolated consecutively from various clinical samples like Pus, Blood; wound Swab, Sputum, urine, etc. Received at Department of Microbiology of JLN Medical & AG of Hospitals, Ajmer and Rajasthan for bacteriological culture and sensitivity. The samples obtained were processed for culture of the bacteria as per routine standards methods. Detection of VRE and HLAR is done. Chi- square was used to compare differences in resistance to anitibiotics among the entercoccal species. A þ value of <0.05 was used to indicate significant differences.rnResult: 125 (3.53%) pure enterococcal isolates were recovered from 3534 specimens. The most frequent source of enterococcal isolations in this study was urine (63.20%) and greater rate of isolation of enterococci from patients admitted in wards (88.80%) as compared to isolates from outdoor patients (11.20%; representative of general population) Overall, this study revealed E.faecalis as the most common species (63.20%) followed by E.faecium (34.40%) and the rest species (2.46%) including E.hirae (1.60%) and E.durans (0.80%) the isolates were resistant to Penicillin (53.6%), Ampicillin (44.80%), high – level gentamicin (53.60%), Erythromycin (98.40%), Tetracycline (20.00%), Ciprofloxacin (76.00%), Quinupristin / Dalfopristin (55.20%). None of the isolates were resistant to linezolid. Two (1.60%) strains were resistant to vancomycin and Teicoplanin.All the strains (100%) in this study were resistant to Erythromycin.It was reassuring that 98.73% and 77.21% of the E.faecalis and 97.67% and 13.95% of the E.faecium in this study were vancomycin and Ampicillin susceptible, respectively. None of the isolate was resistant to linezolid and Tetracycline resistance was found only in 20.00% of isolates, suggesting their possible role in VRE, HLGR and multi-drug resistant infection.rnConclusion: The most frequent source of enterococcal isolations in this study was urine (63.20%) and greater rate of isolation of enterococci from patients admitted in wards (88.80%) highlights the organisms as one of the important cause of nosocomial urinary tract infections.Overall, in the present study, the isolates were resistant to Penicillin (53.6%), Ampicillin (44.80%), high – level gentamicin (53.60%), Erythromycin (98.40%), Tetracycline (20.00%), Ciprofloxacin (76.00%), Quinupristin / Dalfopristin (55.20%). None of the isolates were resistant to linezolid. Two (1.60%) strains were resistant to vancomycin and Teicoplanin.
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How to cite this article:
Dr. Surbhi Mathur. Study of antimicrobial resistance in enterococci at J.L.N medical college and associated Group of Hospitals, Ajmer, Rajasthan. International Journal of Medical and Health Research, Volume 2, Issue 5, 2016, Pages 01-09
International Journal of Medical and Health Research