Efficacy of Unani formulations in the management of dysfunctional uterine bleeding-A randomized controlled trial
Geetha BN, Ismath Shameem
Back ground & objectives: Dysfunctional uterine bleeding (DUB) is a common debilitating problem amongst women in all age groups and accounts for 20% of gynecology office visits. The aim of the study was to evaluate the efficacy of Unani formulations in the management of dysfunctional uterine bleeding.
Methods: A standard controlled randomized single blind study was carried out at National Institute of Unani Medicine Hospital, Bangalore. Patients (n=40) of reproductive age group with dysfunctional uterine bleeding were randomly allocated to test (n=20) and control (n=20) groups. In test group, Unani formulations (safoof habis and majoon muqawwi rehm sada), each in a dose of 6 gm twice daily during an active bleeding phase and interval respectively; while in control group, standard drug (norethisterone acetate-5mg) three times daily during an active bleeding phase followed by 5mg once daily for 21 days. The above interventions were administered orally for three consecutive cycles. Primary outcome measures were to assess the effect of test drugs on menstrual regulation and pictorial blood assessment chart (PBAC) score. Secondary outcome measures were changes in endometrial thickness and hormonal profile.
Results were analyzed using appropriate test. Results: Menstrual regulation was achieved in 58.8% patients in test and 63.2% in control groups (P= 1.000); improvement in PBAC score was observed in 100% patients in both the groups (P = 1.000). No significant changes were observed in endometrial thickness and hormonal profile in either group.
Conclusion: The effect of Unani formulations was comparable with that of control drug; hence it can be used as an effective alternative in the management of dysfunctional uterine bleeding.
Geetha BN, Ismath Shameem. Efficacy of Unani formulations in the management of dysfunctional uterine bleeding-A randomized controlled trial. International Journal of Medical and Health Research, Volume 2, Issue 5, 2016, Pages 57-61