Interleukin-6 and Tumor Necrosis Factor-α has the major role in the cardiovascular diseases. The role of IL-6 in causing cardiovascular disease, ageing related problems, congenital heart problems in children and elderly are now the major target in research for finding solution to cardiovascular problems. The increased levels of IL-6 causes all these problems which are mainly due to polymorphism in gene coding for IL-6. The tumor necrosis factor-α is also found to be associated with the cardiovascular problems. The increased TNF-α levels cause nutritive stress thereby damaging the endothelial function. The increase in TNF-α level is also found to be associated with gene polymorphisms, leading to increased risk of heart failures. In some case it acts as a biomarker, especially in elderly heart failure patients, and the gene polymorphisms of TNF-α were correlated with coronary artery disease. Concisely, some SNP may increase the risk of Cardiovascular diseases.