Background and aim: It is supposed that omega-3 fatty acids impacts on psychiatric disorders, in this study we evaluated the impact of erythrocyte omega-3 fatty acids compositions on psychotic disorders: schizophrenia, major depressive disorder and suicide attempted using chemometric based classification

Materials and Methods: In 125 patients with schizophrenia, major depressive disorder, suicide attempted and healthy control, we used Varian gas chromatography instrument, utilizing an omega wax 250 capillary column (30m× 0.25mm I.D.) and flame ionization detector to measure erythrocyte membrane n-3PUFAs composition and analyzed based chemometric classification

Results: 125 patients (51 male, 74 female) more than 15 were evaluated. In the control group the level of n-3 PUFA and subtypes of n-3 PUFA significantly was more than other groups. Correlations between subtypes 22:6n-3(DHA), 20:5n-3(EPA), 22:5n-3 and Beck Depression Inventory scale (BDIS) was significant. This study compares results obtained with chemometric methods: SIMCA and PLS-DA. The PLS-DA prediction was better than SIMCA in MDD and suicide attempted. In both techniques, the prediction rate for schizophrenia was 100%.

Conclusion: We revealed the level of erythrocyte omega-3 fatty acids compositions in patients with schizophrenia, major depressive disorder and suicide attempt was lower than healthy population, moreover regarding chemometric methods, PLS-DA was slightly better than SIMCA.