International Journal of Medical and Health Research

We studied 25 cases of gestational trophoblastic diseases from March- September 2014 aiming to monitor βHCG level pre-evacuation, 48 hours post evacuation and the following eight weeks post evacuation. Eight cases received chemotherapy and 17 cases without chemotherapy. During the study, we identified 19 cases vesicular mole (VM), 4 cases partial mole (PM) and 2 cases Choriocarcinoma. The mean age of our patients was (19±0.9 to 29±7) and the mean values of β-HCG was decreased rapidly and significantly post evacuation. A slower decline in the next 3weeks and a steady very slow decline after the 4th week. No significant difference between chemotherapy received cases and other cases regarding the decline in β-HCG. We conclude that good evacuation is the mainstay of treatment for molar pregnancy. Chemotherapy should be postponed as we can if no significant rise occurs post evacuation of VM and PM. Post evacuation chemotherapy should begin after the 4th week if βHCG level is more than 20,000mIU/ml. We advised to postpone chemotherapy if levels are lesser than that and do another evacuation after the 8th week if βHCG level is more than 5000mIU/ ml and not to use chemotherapy except if the level not returns to normal after that.