International Journal of Medical and Health Research

Authors
Dr. Pooja Patwa, Dr. Kalpana Desai, Dr. Pragna Vachhrajani, Dr. Pratiti Gohil

Abstract
AIM: This study was done to compare the cost-effectiveness and utilization of volatile anaesthetic drugs, to ascertain the depth and adequacy of anaesthesia by using bispectral index monitoring in patients in general anaesthesia. Material and Methods: In this prospective randomized controlled study, 64 patients of either sex between age group of 18-64 years (ASA I and II) were allocated into four groups. Group 1:O2+N2O+Isoflurane+inj vecuronium 0.1 mg/kg+IPPV without BIS monitoring. Group 2:O2 +N2O+Isoflurane+inj vecuronium 0.1mg/kg+IPPV with BIS monitoring Group 3:O2+N2O+Sevoflurane+inj vecuronium 0.1mg/kg+IPPV without BIS monitoring Group 4:O2+N2O+Sevoflurane+inj vecuronium 0.1mg/kg+IPPV with BIS monitoring General anaesthesia was administered by usual method and maintained on O2+N2O+isoflurane/sevoflurane. All patients were monitored vitally every 10 mints interval. BIS monitoring is done in group 2&4 and BIS value was kept between 40-60. Requirement of inhalational agents and recovery time were calculated. Post-operative vital data, sedation scale and side effects were recorded. Results: Recovery of patient was faster in BIS titrated group (Group II&IV) as compared to control group (Group I&III) (P<0.05).Total volume of volatile anaesthetic agent Isoflurane and sevoflurane used was significantly lower in BIS titrated group than control group (P<0.001). In BIS guided anaesthesia patient remained hemodynamically stable throughout surgery. Conclusion: Titrating isoflurane and sevoflurane using BIS monitor decreased their utilization and contributed to a faster emergence from anaesthesia.