Wound and their management are fundamental to the practice of surgery. From practical point of view wounds are classified into tidy wound and untidy wound by Rank and Wakefield. A clinical prospective study was done in the department of plastic surgery, GMCH, Assam for a period of one year from June 2015 to June 2016 on negative pressure wound therapy: a clinical study on its efficacy, cost effective and use in the treatment of wound in plastic surgery. Patients who had either acute or chronic wound were included. Exclusion criterias include exposed vessels, uncontrolled diabetic, wound containing malignant tissue and patient refusal. A total of 10 patients were included in the study and it comprises of 4 female and 6 males. There were 2 chronic wounds and 8 cases of acute wound. NPWT plays an important role in the wound management and helped in the wound healing. It reduced the hospital stay and improved quality of life and patient compliance and thereby the cost of treatment.