Role of bone morphogenic protein in osteoporotic fracture a study done on rat models

Dr. AN Mishra; Dr. Gajendra Kumar

Role of bone morphogenic protein in osteoporotic fracture a study done on rat models

Authors
Dr. AN Mishra, Dr. Gajendra Kumar

Abstract
Introduction: Osteoporosis is a common helth problem of elderly peple and post menopausal female in whom aesnogen withdrawal leads to further decrease in bone density. Low bone mass in osteoporotic bone make the bone fragile and more susceptible to fracture. Bone morphogenic protein play a critical role in it. It was initially discovered as component of deminiralised bone extracts that promote bone heading. Aim of this study was to determine the effect of single dose of bone morphogenic protein (BNP-7) Plus a collagen composite in fracture healing in osteoporotic rat models.

Methods: 40 Albino Female rat. Ovarectomy was done. After three months mid shagt fracture of femur on the left side was performed and the fracture was fixed with K-wire 1.6mm diameter. Rats were randomized into groups each group has (n=20). One group was given BMP-7+ collagen- I 68.77mg collagen-I. Collagen –I alone was used in other group (0.2ml) as control at the fracture site Muscle and skin were than colosed at the end of the procedure. Rats from each group were examined at day 12, 20 and 31 post surgery. X-ray film was taken in each rats in frontal projection.

Observation: Radiographs were examined to numerically descrife the callus fromed in both groups. Significant enhancement in callus formation and maturity was observed in the group treated with BMP-7 at all point of time. Bridging callus and fracture remodeling was visible in radiographs of BMP-7 treated group which indicates more active. Fracture healing in the presence of BMP-7 that in coutrol group.

Conclusion: Osteoporosis is a growing health problem. It is charactensed by a high risk of bone fracture and the healing process is also retarded. There are few treatment options available for osteoporosis. This studay shous that BMP-7 increases healing potety in long bone fractures in experimental rat models BMP-7 stimulates new bone formation increases bone mineral density and enhancks the strength of bone as compared to control.

Download | Pages : 57-58