Lowe syndrome (Oculocerebrorenal syndrome of Lowe) is a rare X-linked recessive disorder characterized by the involvement of the eyes, brain, and kidneys. The causative gene is OCRL1. Survival rarely exceeds 40 years. I am reporting on a two-month-old male infant who presented for a 2-month vaccination visit, and was found to have an eye problem (cataract), a brain problem (hypotonia with MRI finding of hypoxic ischemic encephalopathy), and renal problems (left multicystic kidney and ectopic right kidney), which is actually the diagnosis of LOWE syndrome.