Pediatric liver transplants accounting for 10-15% of all liver transplants worldwide occur due to congenital defects. The main etiological factors behind liver transplantation are congenital liver defect. The American Liver Foundation published a ‘Pediatric Liver Research Agenda which advocate that a better understanding of embryonic liver development would provide important insights into treatment and preventive strategies for pediatric liver disease. The present study aims to see the detail histogenesis and development of human liver in prenatal period.