Materials & Methods: A retrospective review of 21 cases of ectopic pregnancy from October 2015 to June 2017 who received systemic methotrexate at MGM Medical College, Jamshedpur, Jharkhand.

Results: There were total of 21 cases included in the study who received systemic methotrexate. Of these 13 (62%) cases were successfully treated with single dose of injection methotrexate. Four patients (19%) required additional dose of injection methotrexate. Total 17 case out of 21 (81%) were successfully treated with systemic methotrexate.

Four cases (19%) who received single dose of inj methotexate underwent surgery (having failed medical treatment) for tubal abortion/tubal rupture.

Conclusion: With early diagnosis and adopting proper selection criteria medical treatment of ectopic pregnancy with systemic methotrexate is on effective and safe alternative to surgical treatment.