Medical students, particularly the first year students who are in the transition phase of their life, are the most vulnerable for developing stress. Many researchers have reported a relationship between stress and blood pressure. In fact, the natural reaction of the cardiovascular responses to the stress is the increase in the heart rate. Hence the present study has been conducted to shown acute effect of examination stress on cardiovascular parameters. This study was carried upon 70 male medical students who were appearing in university practical examination. Two recordings of blood pressure and pulse rate were recoded of those students. First Pre examination recording of Blood Pressure and Pulse rate of the students were taken thirty minutes prior to the university Practical and Viva-Voice examination and second Post examination recording of blood pressure and pulse rate of the students were taken just after one day of the examination. In our study we found that pre examination values of pulse rate and Blood Pressure was higher than the post examination values.