Raised levels of serum prolactin which arises in CKD may contribute to vascular derangements. This might lead to worse cardiovascular consequences amongst CKD patients. Hence the present study was planned to assess the serum prolactin levels in CKD patients. The study has planned in IGIMS Patna, The 50 patients diagnosed with chronic kidney disease were enrolled in to the study. The age group of the patients are from 25-65 years. The data generated in the present study showed that Hyperprolactinemia is detected in 52% of patients with CKD. From the above findings it can be concluded that CKD is associated with increased serum levels of hormone prolactin (Hyperprolactinemia).