Significance of Hba1c and lipid profile test in diagnosis and prognosis of diabetic and cardio vascular patients
Diabetes Mellitus (DM) is characterized by chronic hyperglycemia with disturbances of Carbohydrate, Lipid and Protein metabolism resulting from defects in insulin secretion, insulin action or both. Obesity is an independent risk factor for cardiovascular disease, including coronary artery disease and congestive heart failure, in both men and women. Glycated hemoglobin (HbA1C) is a routinely used marker for long-term glycemic control. Elevated HbA1c has been regarded as an independent risk factor for coronary heart disease (CHD) and stroke in subjects with or without diabetes. Aim & Objectives: To evaluate the level of HbA1C and lipid profile in type 2 diabetes mellitus patients. To find out the correlation between HbA1C and lipid profile parameters in type 2 diabetic population. Methodology: This Cross sectional study was conducted among type 2 diabetic patients and control subjects and they were divided into three groups. Group 1- control subjects = 28, Group 2– Type 2 DM with good control = 28 and Group 3– Type 2 DM with poor control = 28.The serum sample was used for the measurement of total Cholesterol, Triglycerides, HDL, LDL and VLDL. Fasting and postprandial (2 hour) blood sugar (FBS & PPBS) were estimated by Glucose Oxidase-Peroxidase (GOD-POD) enzymatic end point method. HbA1C was estimated by using Ion exchange chromatography (Crest a Coral clinical system, USA). Urine examination was done for benedicts test and proteinuria. Statistical Analysis was done by using SPSS version 75.0. Results: Our study showed significant correlation between HbA1C and lipid profile parameters between the two groups (less than 7% and more than 7% of HbA1C). The results suggested the importance of glycemic control in order to manage dyslipidemia and risk for cardiovascular disorder in type 2 diabetes. Conclusion: This dual biomarker- HbA1C, glycemic control as well as lipid profile can be used for screening of high risk patients for early diagnosis of dyslipidemia thereby the cardiovascular and peripheral complications can be prevented by timely intervention of the disease.
Dr. Anand. Significance of Hba1c and lipid profile test in diagnosis and prognosis of diabetic and cardio vascular patients. International Journal of Medical and Health Research, Volume 3, Issue 2, 2017, Pages 105-109