Congenital hypothyroidism is the most common preventable cause of mental retardation. The premature inborn neonates admitted to NICU in North India were considered in the study. Due to the established relationship of lower levels of the thyroid hormones and septic shock; this study has planned to evaluate the imbalanced Thyroid function test associated with the hypotension The inborn premature neonates having gestation age of 30-35 weeks diagnosed with sepsis are studied. Two study groups were enrolled into the study. Group A Neonates having with sepsis and fluid-resistant hypotensive shockand Group B: Neonates having those with sepsis but no shock. Our study expressed that low levels of T3, T4 and TSH are linked with fluid-resistant hypotensive shock among septic preterm neonates, but, after adjusting for the level of sickness, TFTs are not independently associated with shock or mortality. Hence from the above data it can be concluded that no factor is independently responsible for the septic shock among premature neonates. Also thyroid hormone levels do not individually envisage occurrence of shock amongst septic premature neonates.