Women with PCOS are at possibility for infertility and premature pregnancy damage. Numerous are overweight, find it problematic to lose weight, and suffer with fatigue, depression and anxiety. Therefore, this study was planned to estimatelevels of the LH, FSH, Prolactin and TSH. The study is conducted in Katihar Medical College and Hospital in Pharmacology department. The approval of ethical committee had been taken along with the consent from the patients were also taken. Total 50 patients having are group of 20-50 years were enrolled in to the study and divided as case and control. The PCOD cases of patients had seen higher levels of the LH, FSH, TSH and Prolactin levels as compared to normal study group patients. All women with PCOS should have their thyroid function tests evaluated thoroughly. Women with PCOS are at possibility for infertility and premature pregnancy damage. Numerous are overweight, find it problematic to lose weight, and suffer with fatigue, depression and anxiety. More studies should be carried to reveal the precise relationship of hypothyroidism in the context of PCOS.