Surgery conveys a stress reaction resulting in numerous biochemical and hormonal changes. Hormonal interaction is the key role, in the development of stress response, which has been projected as hyperglycemic response. The aim of the study is to demonstrate that well well-adjustedanesthesia in controlled diabetic mellitus patients; the rise of blood sugar is not significant when compared to non-diabetic patients. First fasting blood sugar levels were assessed pre operatively by glucometer with glucose oxidase strip by standard capillary method. The blood glucose levels were monitored at Preoperative, 5 mins after intubation, 30 mins after intubation and 5 mins after Extubation stages. This study gives an understanding into conquest of stress response of surgery by using various anaesthetic drugs in general anaesthesia. This information allows us to choose on the use of various anesthetic drugs, which will better control the surgical stress and reductions the morbidity in patients subjected to various degrees of surgeries.