Introduction:Osteo-arthritis is the most frequent cause of musculoskeletal disability. It is a common disorder of synovial joints characterised by destruction of hyaline articular cartilage, and reactive bone changes. Materials and Methods: The components of metabolic syndrome like waist circumference, blood pressure, total triglycerides, HDL cholesterol and fasting glucose were measured. Results: HDL cholesterol levels between controls and cases were found to be highly significant. Conclusion: The present study shows that there is increased association of adversely changed components of metabolic syndrome with osteo-arthritis.