Osteoarthritis is an age related problem which decline in the synthesis of Glucosamine in our body. Due to the reduction in the glucosamine sulphate concentration at joint cartilage ground substance Chondroitin sulphate declines. Hence, the study was aimed to compare the efficacy and safety of Glucosamine sulphate and Placebo control tablets in selected primary Osteoarthritis patients. The randomised, Double blind and Comparative study was carried out with 60 patients in tertiary care teaching Hospital, Coimbatore. Thirty patients in each group as per Inclusion criteria after treatment, which was followed for 5 months. Patients with Glucosamine for 3 months therapy had significant reduction, effectiveness in Swelling joints, Painful joints and Morning stiffness. The duration of walking 50 feet was increased in patients with Glucosamine. The study concludes that Glucosamine shows significant effect in reduction in symptoms and increase the quality of life.