Irritable bowel syndrome (IBS) is regarded as disorder of brain gut axis, with altered central nervous system processing. Limited data is available regarding epidemiology and clinical profiling of constipation predominant IBS (IBS-C) in the general Indian constipated population. Hence the present study was conducted to evaluate the demographics, socio-economic and clinical characteristics in these patients. Patients (≥18 years) satisfying Rome-III criteria for IBS-C were enrolled in this prospective, multicentric, clinico-epidemiological study. Their demographics, socioeconomic status (Kuppuswamy scale), comorbid conditions, concomitant medications, severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (PAC-QoL) were assessed. Out of 925 patients of constipation, 226 (24.43 %) patients fulfilled the Rome-III criteria for IBS-C were enrolled; rest of 75.57 % patients had functional constipation. Mean age of study population was 43.8 ± 16.3 years (men: 65.5%; women: 34.5%); higher proportion of patients were from urban population compared to rural (62.0 % vs. 38.1 %). Patients had higher mean scores of education and occupation and belonged to upper socio-economic class. Patients had higher mean scores of PAC-SYM (30.1±4.9) and CSS (11.2±3), leading to poor quality of life (PAC-QoL: 42.2±13.6). Acid peptic disorders (APD; 21.7%) and hypertension (13.7%) were the most common comorbidities reported. Laxatives (50.9%), drugs for APD (40.7%), antihypertensive (14.2%) and antianxiety/antidepressants (12.8%) were the most commonly used concomitant medication. Higher educational/occupational scores point towards increased stress/anxiety, which could be attributed to dysfunctional brain-gut axis in IBS. Patients with IBS-C reported high frequency and severity of constipation-related symptoms, thereby leading to poor QoL. Moreover, these patients had higher prevalence of APDs, thus highlighting the need to identify the presence of upper gastrointestinal comorbidities in IBS patients. This study thus emphasizes the necessity for a multi-faceted approach for holistic management of IBS.