Negative pressure assisted wound healing is a recent proven method of fast and better healing of wounds. The application of negative pressure to remove edema fluid from the wound through suction. This results in increased blood flow to the wound (by causing the blood vessels to dilate) and greater cell proliferation. Another important benefit of fluid removal is the reduction in bacterial colonization of the wound, which decreases the risk of wound infections. Through these effects, Negative pressure-assisted closure enhances the formation of granulation tissue, an important factor in wound healing and closure.