The main objective of this double blinded case-Control study was to evaluate the role of Intravenous Tranexamic Acid therapy in reducing total blood loss in patients undergoing joint replacement surgeries. Group A had administrated with the Normal Saline (0.1 ml/kg) and Group B patients were administered with the Tranexamic Acid (0.1 ml/kg). The blood loss during surgery is seen more in the patient administered with the normal saline patients, where as the patient administered with the Tranexamic Acid show lower amount of blood loss. Similar observations were seen the blood loss during the post-operative drain. The difference in the Haemoglobin in the Pre-Operative and post-operative conditions also suggest the narrower difference the Tranexamic Acid administered patients. Tranexamic acid is effective in reducing perioperative blood loss when given by infusion. Continuation of an infusion postoperatively is more useful than a single dose in decreasing blood loss in the first 6 h after surgery. Tranexamic acid significantly reduces the need for allogenic blood transfusion.