International Journal of Medical and Health Research

Authors
Dr. Pulak Raj, Dr. Rajesh Kumar Khare

Abstract
Background: 5'-nucleotidase is an enzyme which catalyzes the phosphorylytic cleavage of 5'nucleotides. The present study was conducted to assess the level of 5’-nucleotidase activity in viral hepatits, alcoholic liver disease and liver cirrhosis. Materials & Methods: This study was conducted in the department of general medicine in year 2015. It included 66 patients. They were divided into 3 groups based on clinical and histopathological examination. Each group had 22 patients. 5’ NT level was measured in each patient. Results: Group I was viral hepatits group containing 22 patients, group II was Alcoholic liver disease group containing 22 patients and group III was liver cirrhosis group containing 22 patients. In group I, serum 5’ NT level was 32.4± 6.20, in group II, 26.54± 4.18, in group III, 22.86± 4.2 and in group III it was 10.4± 1.6. The difference was significant (P- 0.05). Conclusion: The level of 5’nucleotidase level is raised in viral hepatits patients, Alcoholic liver disease patients and liver cirrhosis patients. This level is useful in determination of diseases affecting liver.