Effect of perinatal beta cypermethrin exposure on the biochemical profile of rat off spring
Victoria Chinenye Obinna, Hope Delesi Kagbo
Cypermethrin, a broad spectrum pesticide, extensively used for pest management and animal husbandry practices has resulted in severe environmental pollution and health hazards. Previous studies have shown that cypermethrin has teratogenic effect on rat foeti born to exposed dam or buck with no information on its effect on their biochemical profile. The present study was aimed to measure the serum and tissue biomarkers (AST, ALT, MDA, CA, SOD and GSH) of rat offspring exposed to beta cypermethrin (β-cyp) during the perinatal period. Fifteen pregnant animals (Day 0 = day of mating, average body-weight = 190g) were randomly divided into 3 groups. Group A (Control) received 0.5ml olive oil, Group B (15 mg/kg β-cyp) and Group C (30 mg/kg β-cyp) by oral gavage from gestational day (GD) 1 – post natal day (PND) 20. On PND 21, blood, liver and kidney samples were collected from 5 pups from each group for biochemical assay. β-cyp caused a significant (p< 0.05) increase in the AST activities and slight but not significant (p>0.05) increase in activities of ALT of the β-cyp exposed rat offspring relative to the control. β-cyp also caused a significant (p<0.05) reduction in the Hepatic MDA and CA levels and a non significant (p>0.05) change on the hepatic GSH & SOD, and the renal MDA, CA, GSH and SOD of exposed rat offspring relative to the control. It is therefore concluded that β-cyp can alter the biochemical profile of albino rat offspring exposed during the perinatal period.
Victoria Chinenye Obinna, Hope Delesi Kagbo. Effect of perinatal beta cypermethrin exposure on the biochemical profile of rat off spring. International Journal of Medical and Health Research, Volume 4, Issue 1, 2018, Pages 07-10