Background: Thalassemia is a group of hereditary anaemia characterized by reduced or absent globin chain, resulting in transfusion dependent anemia and iron overload.

Objectives: Evaluation of thyroid profile in thalassemia children and its correlation with serum ferritin in children.

Methods: This is a prospective study including 70 children of thalassemia who are on regular blood transfusion and whose ferritinis >1000μgm/dl. Assessment of their thyroid profile and its correlation with serum ferritin was done.

Results: Hypothyroidism was found in around 38% children in our study. Amongst which 31.43% had subclinical hypothyroidism and 7.14% had overt hypothyroidism. We found statistically significant difference in mean serum ferritin level in euthyroid and hypothyroid group

Conclusion: Periodic thyroid testing must be done to detect hypothyroidism for planning timely replacement of hormone to prevent growth failure. There is strong association between ferritin and thyroid disorder which increases the need of chelation therapy to avoid iron toxicity.