With the rapid growth of microbial genome sequencing and bioinformatics analysis tools, we have the potential to examine all the genes and proteins from any human pathogen Recent advances in cellular and molecular biology have led to the development of new strategies for vaccines against many types of infectious diseases. It has long been recognized that individuals who recovered from a disease developed subsequent resistance to the same. In the late eighteenth century, Edward Jenner developed and established the principle of vaccination using the cross protection conferred by cowpox virus, which is non-pathogenic in humans.

Vaccination may be an important adjunctive therapy to mechanical debridement in near future. Its not a myth but a reality which will come true in the near future if research is carried out in right way in right direction.