Aim: The aim of this study is to evaluate the role of combination of mifepristone and misoprostol in first trimester termination of pregnancy, regarding safety, efficacy, acceptability and complication. Materials and Method: The study was conducted at Rajendra Institute of Medical Sciences, Ranchi in department of Obstetrics & Gynaecology from December 2016 to February 2017. The cases were selected from 200 patients (prescribed and non-prescribed) attending OPD & Labour Room of the department of Obstetrics & Gynaecology. Results: In my study, 83(41.5%) cases were prescribed out of which 72 and 10 were complete and incomplete respectively, followed by 1 case of failure. To this 117 (58.5%) out of total were non-prescribed out of which 62 and 54 were complete and incomplete respectively followed by 1 case of failure. In my study, side effects like fever occurred in 12.5% cases, nausea 9% cases, diarrhea 7.5% cases, rigor 6.5%, headache 6%, and vomiting 5% cases. Conclusion: Unsafe abortion has a shocking picture of one women dying every seven minutes world-wide and in India one women every 2hrs. Unsafe abortion has a shocking picture of one women dying every seven minutes world-wide and in India one women every 2hrs.