Background: Dyspepsia refers to acute, chronic, or recurrent pain or discomfort centered in the upper abdomen. An international committee of clinical investigators (Rome III Committee) has defined dyspepsia as epigastric pain or burning early satiety, or postprandial fullness Dyspepsia occurs in 15 % of the adult population and accounts for 3% of general medical office visits. Method: The descriptive study was carried out in Eastern Afghanistan, Nangarhar Regional Hospital, Medical ward, Department of Gastroenterology, during the year of 2017-18. To know the clinico-endoscopy of dyspepsia, for patients who present with investigated dyspepsia to Gastroenterological OPD & IPD. Result: The study showed that the patients under 30 years of age having 34% of dyspepsia while more than 60 year old patients resulted 14%. About 47% of cases were observed in Nangarhar province while 25 %, 9% and 2% cases were in Laghman, Kunar and Nuristan, province due to higher population and location of the hospital in Jalalabad city,The data resulted that the higher number of patients having Gastritis fallowing NFD and Duodenal ulcer about 32%, 23% 18%, Regarding the habits in our study in which total 100 patients were examined 42% of the above patients had snuff habits, 22% had smoking habits, 2% had alcohol habits and 34% of the total patients doesn't had any habits (majority of them were using spicy food, overfeeding, drinking of nonalcoholic beverages, fatty foods, NSAIDs...) Conclusion: the higher incidence of dyspepsia was in more than 60 year of age, 47% of patients was from nangarhar, the endoscopy showed that 32% patients had gastritis also higher incidence regarding the habits 42% had snuff habit and 22% had smoking habit.